The basic chemistry was first developed by Grünenthal GmbH in 1962 and, after fifteen years of work to refine the drug and produce the maximum level of effectiveness, it was launched on the market in 1977. With more than thirty years of sales all around the world, Tramadol is the painkiller of choice because:

• over thirty years, doctors and their patients have delivered decades of proof that Tramadol is safe and effective;
  
• it controls moderate to severe pain with only a very small risk of side effects;
• it allows people to stay mobile following injury, illness or surgery; and
• with pain controlled, it gives people with both acute and chronic conditions a good quality of life.